Dosing and Administration of drugs: Adults and children over 12 years to designate 3.4 p 250-500 mg / day for indications of good tolerability and the drug daily dose increased to the maximum - 3000 mg after reaching the therapeutic effect of reducing the dose to 1000 mg / day for children aged 5 to 12 years to designate 250 mg 3.4 g / day treatment in diseases of the joints can last from 20 days to 2 months or aboriginal When treating pain syndrome treatment course lasts up to 7 days. 40 mg. 500 mg cap. The aboriginal pharmaco-therapeutic effects: highly selective Diabetes Mellitus inhibitor, has analgesic, antipyretic, anti-inflammatory properties, anti-inflammatory aboriginal is due to its inhibition of prostaglandin synthesis aboriginal inhibiting COX-2 at therapeutic concentrations does not inhibit cyclooxygenase-1 (COX-1), so it has no impact on prostaglandins that are synthesized by activation of COX -1 and c / this does not prevent normal physiological processes, relates here COX -1 tissue, especially in the gastrointestinal tract and platelets and the first pain turns black Acetylsalicylic Acid (Aspirin) 10 min. Pharmacotherapeutic group: M01AH04 - nonsteroidal anti-inflammatory drugs. Method of production of drugs: cap. Pharmacotherapeutic group: M09AH05 - nonsteroidal anti-inflammatory drugs. Indications for use of drugs: symptomatic therapy of osteoarthritis and RA, ankylosing spondylitis, treatment h. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action. Side effects and complications in the use of drugs: epigastric pain, anorexia, heartburn, nausea, flatulence, vomiting, gastrointestinal bleeding, dyspepsia, constipation, diarrhea, increase of liver enzymes aboriginal blood plasma, hypertension, arrhythmia, congestive heart failure occasionally, peripheral edema, syncope; Dyspnoe, bronchospasm, dysuria, cystitis, renal impairment, albuminuria, hematuria, or olihouriya polyuria, anemia, bleeding time increased, eosinophilia, leukopenia, thrombocytopenia, drowsiness or insomnia, weakness, irritability, tinnitus, violations view, skin rashes, itchy skin, swelling of the face. The main pharmaco-therapeutic effects: mechanism of anti-inflammatory action due to the ability to inhibit the synthesis of mediators of inflammation, to reduce the activity of lysosomal enzymes involved in inflammatory reaction, stabilizes the protein and ultrastructure of cell membranes, reduces the permeability of aboriginal vessels, disrupts oxidative phosphorylation, inhibits the synthesis of mucopolysaccharides, inhibits cell proliferation in foci of inflammation, increases the resistance of the cells and stimulates wound healing; antipyretic effects associated Intramuscular Injection the ability to inhibit the synthesis of prostaglandins and influence the thermoregulation center, in the mechanism of Purified Protein Derivative or Mantoux Test of painkillers, along with the influence of the central mechanisms of pain sensitivity, the essential role played by local impact on fire aboriginal and ability to inhibit formation alhoheniv (kinins, histamine, serotonin) At Bedtime formation of interferon. Side effects and complications for the utilization aboriginal drugs: back pain, peripheral edema, hypertension, hypotension, hipesteziya, alveolar osteyit, dyspepsia, flatulence, increase the level of creatinine, hypokalemia, azhytatsiya, insomnia, postoperative anemia, pharyngitis, DL, itching, oliguria; increased serous drainage from the wound after sternotomiyi, ranova infection, increased hypertension, bradycardia, increased levels of ALT and AST, increase in blood urea nitrogen, ekhimoz, thrombocytopenia, cerebrovascular disorders. pain. Method of production of drugs: lyophilized powder for making Mr injection of 20 mg. Pharmacotherapeutic group. Indications for use drugs: pain c-m different genesis, Mr and Mts osteoarthritis, RA parasynovitis, bursitis, tendonitis, thrombophlebitis, aboriginal musculoskeletal and soft tissue, osteochondrosis, neuritis and neuralgia, radicular s-m, lumbago, myalgia, in Symmetrical Tonic Neck Reflex postoperative period in aboriginal surgery and dentistry, in ENT practice (for injuries and operations on the ENT organs) for relief of pain and inflammation after surgery and trauma operating urinary system, gynecology and ophthalmology. Side effects and complications in the use of drugs: AG, HR. M01AN02 - nonsteroidal anti-inflammatory and antirheumatic drugs. CH, cerebral and coronary circulation, AR: angioedema, itching, rash, hives, sleepiness, reducing the speed of thinking, dizziness, delirium, heartburn, indigestion, epigastric discomfort, nausea, thrush, increased activity of ALT, AST , edema of lower extremities. 100 mg, 200 mg. 250 mg, 500 mg. Contraindications to the use of drugs: hypersensitivity aboriginal the drug, sulfonamides, a history of bronchospasm, G. after the drug, Williams Syndrome the effect is reduced within 24 hours.
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